Reactome | Expression of Erythropoietin (EPO)

Schema > BlackBoxEvent > Entries

Expression of Erythropoietin (EPO) Show undefined attributes

authored	[InstanceEdit:1235032] May, B, 2011-03-20
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:1235038] May, B, 2011-03-21
dbId	1235070
displayName	Expression of Erythropoietin (EPO)
edited	[InstanceEdit:1235038] May, B, 2011-03-21
eventOf	[Pathway:R-HSA-1234158] Regulation of gene expression by Hypoxia-inducible Factor - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5652235] EPO gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1235060] General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia [LiteratureReference:1235066] Purification and characterization of hypoxia-inducible factor 1 [LiteratureReference:1234069] Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1 [LiteratureReference:1235062] An essential role for p300/CBP in the cellular response to hypoxia [LiteratureReference:1235041] Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of Erythropoietin (EPO)
output	[EntityWithAccessionedSequence:R-HSA-379001] EPO [extracellular region]
precedingEvent	[BlackBoxEvent:R-HSA-1234167] Formation of HIF:CBP:p300 complex at promoters - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-1235078] Positive gene expression regulation by 'HIF:CBP:p300 [nucleoplasm]'
regulationReference	[RegulationReference:9641731] Positive gene expression regulation by 'HIF:CBP:p300 [nucleoplasm]' An essential role for p300/CBP in the cellular response to hypoxia
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2255300] Rantanen, Krista, 2012-05-19
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1235070
summation	[Summation:1235050] The EPO gene is transcribed to yield mRNA and the mRNA is tr... [Summation:1235079] The HIF heterodimer binds the promoter of the EPO gene and r...
updateTrackers	[UpdateTracker:9775832] Update Tracker - [BlackBoxEvent:1235070] Expression of Erythropoietin (EPO) - v78:[addSummation] [UpdateTracker:9785054] Update Tracker - [BlackBoxEvent:1235070] Expression of Erythropoietin (EPO) - v52:[addInput]

Referrals

(updatedInstance)	[UpdateTracker:9775832] Update Tracker - [BlackBoxEvent:1235070] Expression of Erythropoietin (EPO) - v78:[addSummation] [UpdateTracker:9785054] Update Tracker - [BlackBoxEvent:1235070] Expression of Erythropoietin (EPO) - v52:[addInput]
(hasEvent)	[Pathway:R-HSA-1234158] Regulation of gene expression by Hypoxia-inducible Factor