Reactome | Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)

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Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) Show undefined attributes

authored	[InstanceEdit:1234185] May, B, 2011-03-18
catalystActivity	[CatalystActivity:1234170] 2-oxoglutarate-dependent dioxygenase activity of FIH1:AscH-:Fe2+ dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643080] 2-oxoglutarate-dependent dioxygenase activity of FIH1:AscH-:Fe2+ dimer [cytosol] Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1234178] May, B, 2011-03-18
dbId	1234164
deleted	[Deleted:9632880] Deletion of instance: 1234162
displayName	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)
edited	[InstanceEdit:1234185] May, B, 2011-03-18
eventOf	[Pathway:R-HSA-1234174] Cellular response to hypoxia - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [DefinedSet:R-HSA-1234109] HIF1A,HIF2A [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1234006] Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing [LiteratureReference:1234094] Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity [LiteratureReference:1234043] Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family [LiteratureReference:1234088] FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor [LiteratureReference:1234019] Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases [LiteratureReference:1235023] Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)
orthologousEvent	[Reaction:R-MMU-1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - Mus musculus [Reaction:R-GGA-1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - Gallus gallus [Reaction:R-XTR-1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - Xenopus tropicalis [Reaction:R-DRE-1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - Danio rerio [Reaction:R-SSC-1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - Sus scrofa [Reaction:R-BTA-1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - Bos taurus [Reaction:R-CFA-1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - Canis familiaris [Reaction:R-RNO-1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - Rattus norvegicus
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [DefinedSet:R-HSA-1234148] hydroxyAsn-HIF1A,HIF2A [cytosol] [SimpleEntity:R-ALL-29434] SUCCA [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-480301] Expression of EPAS1 (HIF2A) - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2255300] Rantanen, Krista, 2012-05-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1234164
summation	[Summation:1235022] HIF1AN (FIH, FIH-1) forms a homodimer that hydroxylates an a...
updateTrackers	[UpdateTracker:9777991] Update Tracker - [Reaction:1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - v68:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777991] Update Tracker - [Reaction:1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - v68:[addLiteratureReference, modifyText]
(replacementInstances)	[Deleted:9632880] Deletion of instance: 1234162
(hasEvent)	[Pathway:R-HSA-1234174] Cellular response to hypoxia

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