Reactome | p-6Y-EGFR L747_T751del [plasma membrane]

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p-6Y-EGFR L747_T751del [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-1182977] Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1228043] Orlic-Milacic, Marija, 2011-03-16
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233
dbId	1228041
disease	[Disease:1247848] non-small cell lung carcinoma
displayName	p-6Y-EGFR L747_T751del [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[ModifiedResidue:182927] O4'-phospho-L-tyrosine at 1069 [ModifiedResidue:179797] O4'-phospho-L-tyrosine at 1092 [ModifiedResidue:179834] O4'-phospho-L-tyrosine at 1110 [ModifiedResidue:179844] O4'-phospho-L-tyrosine at 1172 [ModifiedResidue:179872] O4'-phospho-L-tyrosine at 1197 [ModifiedResidue:180321] O4'-phospho-L-tyrosine at 1016 [FragmentDeletionModification:9626695] Deletion of residues 747 to 751
inDisease	true
literatureReference	[LiteratureReference:1181048] EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
maxDepth	1
modified	[InstanceEdit:9626696] Orlic-Milacic, Marija, 2018-10-29
name	p-6Y-EGFR L747_T751del Phosphorylated Epidermal Growth Factor Receptor L747_T751del p-6Y-EGFR Leu747_Thr751del
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1228041
startCoordinate	25
updateTrackers	[UpdateTracker:9899937] Update Tracker - [EntityWithAccessionedSequence:1228041] p-6Y-EGFR L747_T751del [plasma membrane] - v67:[add_removeHasModifiedResidue] [UpdateTracker:9888274] Update Tracker - [EntityWithAccessionedSequence:1228041] p-6Y-EGFR L747_T751del [plasma membrane] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9899937] Update Tracker - [EntityWithAccessionedSequence:1228041] p-6Y-EGFR L747_T751del [plasma membrane] - v67:[add_removeHasModifiedResidue] [UpdateTracker:9888274] Update Tracker - [EntityWithAccessionedSequence:1228041] p-6Y-EGFR L747_T751del [plasma membrane] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-1182977] Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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