Reactome | p-6Y-EGFR L747_P753delinsS [plasma membrane]

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p-6Y-EGFR L747_P753delinsS [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1228043] Orlic-Milacic, Marija, 2011-03-16
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233
dbId	1228038
disease	[Disease:1247848] non-small cell lung carcinoma
displayName	p-6Y-EGFR L747_P753delinsS [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[ModifiedResidue:182927] O4'-phospho-L-tyrosine at 1069 [ModifiedResidue:179797] O4'-phospho-L-tyrosine at 1092 [ModifiedResidue:179834] O4'-phospho-L-tyrosine at 1110 [ModifiedResidue:179844] O4'-phospho-L-tyrosine at 1172 [ModifiedResidue:179872] O4'-phospho-L-tyrosine at 1197 [ModifiedResidue:180321] O4'-phospho-L-tyrosine at 1016 [FragmentReplacedModification:9628403] Replacement of residues 747 to 753 by S
inDisease	true
literatureReference	[LiteratureReference:1181035] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
maxDepth	1
memberOf	[CandidateSet:R-HSA-1182977] Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9628415] Orlic-Milacic, Marija, 2018-11-08
name	p-6Y-EGFR L747_P753delinsS Phosphorylated Epidermal Growth Factor Receptor L747_P753delinsS p-6Y-EGFR Leu747_Pro753delinsSer
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1228038
startCoordinate	25
updateTrackers	[UpdateTracker:9899753] Update Tracker - [EntityWithAccessionedSequence:1228038] p-6Y-EGFR L747_P753delinsS [plasma membrane] - v67:[add_removeHasModifiedResidue] [UpdateTracker:9888324] Update Tracker - [EntityWithAccessionedSequence:1228038] p-6Y-EGFR L747_P753delinsS [plasma membrane] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9899753] Update Tracker - [EntityWithAccessionedSequence:1228038] p-6Y-EGFR L747_P753delinsS [plasma membrane] - v67:[add_removeHasModifiedResidue] [UpdateTracker:9888324] Update Tracker - [EntityWithAccessionedSequence:1228038] p-6Y-EGFR L747_P753delinsS [plasma membrane] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-1182977] Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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