Reactome | EGFRvIII [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-1248004] EGFRvIII mutant:HSP90:CDC37 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1247999] EGFRvIII mutant binds chaperone proteins HSP90 and CDC37 - Homo sapiens
created	[InstanceEdit:1214163] Orlic-Milacic, Marija, 2011-02-11
crossReference	[DatabaseIdentifier:12021113] Mondo:0021636 [DatabaseIdentifier:1996305] COSMIC:COSM21351
dbId	1214162
disease	[Disease:1247632] glioblastoma [Disease:1996318] astrocytoma [Disease:1996312] brain glioma [Disease:1500689] cancer [Disease:1981182] lung squamous cell carcinoma
displayName	EGFRvIII [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[FragmentDeletionModification:1246108] Deletion of residues 30 to 296 [ReplacedResidue:1996332] L-arginine 297 replaced with glycine
inDisease	true
maxDepth	1
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	EGFRvIII EGFR V30_R297delinsG mutant Epidermal Growth Factor Receptor V30_R297delinsG mutant EGFR Val30_Arg297delinsGly mutant
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1214162
startCoordinate	25
summation	[Summation:1214165] EGFR V30_R297delinsG mutant of EGFR, commonly known as EGFRv...
updateTrackers	[UpdateTracker:9887720] Update Tracker - [EntityWithAccessionedSequence:1214162] EGFRvIII [plasma membrane] - v46:[modifyName]

(updatedInstance)	[UpdateTracker:9887720] Update Tracker - [EntityWithAccessionedSequence:1214162] EGFRvIII [plasma membrane] - v46:[modifyName]
(input)	[Reaction:R-HSA-1247999] EGFRvIII mutant binds chaperone proteins HSP90 and CDC37
(diseaseEntity)	[EntityFunctionalStatus:9630152] gain_of_function of EGFRvIII [plasma membrane]
(hasComponent)	[Complex:R-HSA-1248004] EGFRvIII mutant:HSP90:CDC37 [plasma membrane]

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