Reactome | PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins

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PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins Show undefined attributes

authored	[InstanceEdit:1183167] Jassal, B, 2011-02-10
catalystActivity	[CatalystActivity:1183105] protein-arginine deiminase activity of PADIs:Ca2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1183167] Jassal, B, 2011-02-10
dbId	1183128
displayName	PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins
edited	[InstanceEdit:1183167] Jassal, B, 2011-02-10
eventOf	[Pathway:R-HSA-3247509] Chromatin modifying enzymes - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [OtherEntity:R-ALL-1183111] Protein-L-arginine [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1183150] cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I [LiteratureReference:1183134] Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin [LiteratureReference:1183192] Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin [LiteratureReference:1183149] Human PAD4 regulates histone arginine methylation levels via demethylimination [LiteratureReference:1183110] Comparison of enzymatic properties between hPADI2 and hPADI4 [LiteratureReference:1183178] Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins Protein citrullination
orthologousEvent	[Reaction:R-GGA-1183128] PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins - Gallus gallus [Reaction:R-XTR-1183128] PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins - Xenopus tropicalis [Reaction:R-SSC-1183128] PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins - Sus scrofa [Reaction:R-BTA-1183128] PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins - Bos taurus [Reaction:R-CFA-1183128] PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins - Canis familiaris [Reaction:R-RNO-1183128] PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins - Rattus norvegicus [Reaction:R-MMU-1183128] PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins - Mus musculus
output	[SimpleEntity:R-ALL-29382] NH3 [cytosol] [OtherEntity:R-ALL-1183191] Protein-L-citrulline [cytosol]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1183128
summation	[Summation:1183122] Methylation of histones by protein arginine methyltransferas...

Referrals

(hasEvent)

[Pathway:R-HSA-3247509] Chromatin modifying enzymes