PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins

Stable Identifier
Reaction [transition]
Homo sapiens
Protein citrullination
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Methylation of histones by protein arginine methyltransferases (PRMTs), in general, is required for mammalian development and plays an important and dynamic role in gene regulation. Protein-arginine deiminases (PADIs) catalyse the deimination of L-arginine residues (L-Arg) in proteins to L-citrulline (L-Cit), thus playing a role in the regulation of development (Guerrin et al. 2003, Ishigami et al. 2002, Kanno et al. 2000, Wang et al. 2004, Nakayama-Hamada et al. 2005, Chavanas et al. 2004).
Literature References
PubMed ID Title Journal Year
15345777 Human PAD4 regulates histone arginine methylation levels via demethylimination

Stallcup, MR, Dou, Y, Coonrod, SA, Wang, Y, McDonald, CH, Lee, YH, Cook, RG, Clarke, S, Wysocka, J, Perlin, JR, Allis, CD, Leonelli, L, Sayegh, J, Roeder, RG, Sonbuchner, LS

Science 2004
12392711 Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin

Kuramoto, M, Akiyama, K, Asaga, H, Ishigami, A, Ohsawa, T, Maruyama, N

Arch Biochem Biophys 2002
12416996 cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I

Serre, G, Ishigami, A, Simon, M, Valmary, S, Guerrin, M, Méchin, MC, Sebbag, M, Nachat, R, Senshu, T

Biochem J 2003
11069618 Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin

Yoshiki, A, Kawada, A, Kusakabe, M, Yosida-Noro, C, Yamanouchi, J, Tezuka, T, Kanno, T, Takahara, H, Shiraiwa, M, Manabe, M

J Invest Dermatol 2000
15087120 Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6

Serre, G, Kawada, A, Simon, M, Méchin, MC, Chavanas, S, Nachat, R, Takahara, H

Gene 2004
15629448 Comparison of enzymatic properties between hPADI2 and hPADI4

Furukawa, H, Kawaida, R, Ohsaka, M, Takazawa, T, Nakayama-Hamada, M, Yamada, R, Ono, M, Kasuya, A, Kubota, K, Suzuki, A, Yamamoto, K

Biochem Biophys Res Commun 2005
Catalyst Activity

protein-arginine deiminase activity of PADIs:Ca2+ [cytosol]

Orthologous Events
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