Reactome | PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins

PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins

Stable Identifier

R-HSA-1183128

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein citrullination

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Methylation of histones by protein arginine methyltransferases (PRMTs), in general, is required for mammalian development and plays an important and dynamic role in gene regulation. Protein-arginine deiminases (PADIs) catalyse the deimination of L-arginine residues (L-Arg) in proteins to L-citrulline (L-Cit), thus playing a role in the regulation of development (Guerrin et al. 2003, Ishigami et al. 2002, Kanno et al. 2000, Wang et al. 2004, Nakayama-Hamada et al. 2005, Chavanas et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15345777	Human PAD4 regulates histone arginine methylation levels via demethylimination Stallcup, MR, Dou, Y, Coonrod, SA, Wang, Y, McDonald, CH, Lee, YH, Cook, RG, Clarke, S, Wysocka, J, Perlin, JR, Allis, CD, Leonelli, L, Sayegh, J, Roeder, RG, Sonbuchner, LS	Science	2004
12392711	Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin Kuramoto, M, Akiyama, K, Asaga, H, Ishigami, A, Ohsawa, T, Maruyama, N	Arch Biochem Biophys	2002
12416996	cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I Serre, G, Ishigami, A, Simon, M, Valmary, S, Guerrin, M, Méchin, MC, Sebbag, M, Nachat, R, Senshu, T	Biochem J	2003
11069618	Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin Yoshiki, A, Kawada, A, Kusakabe, M, Yosida-Noro, C, Yamanouchi, J, Tezuka, T, Kanno, T, Takahara, H, Shiraiwa, M, Manabe, M	J Invest Dermatol	2000
15087120	Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6 Serre, G, Kawada, A, Simon, M, Méchin, MC, Chavanas, S, Nachat, R, Takahara, H	Gene	2004
15629448	Comparison of enzymatic properties between hPADI2 and hPADI4 Furukawa, H, Kawaida, R, Ohsaka, M, Takazawa, T, Nakayama-Hamada, M, Yamada, R, Ono, M, Kasuya, A, Kubota, K, Suzuki, A, Yamamoto, K	Biochem Biophys Res Commun	2005