Reactome | p-6Y-EGFR L858R [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-6Y-EGFR L858R [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1173208] Orlic-Milacic, Marija, 2011-01-21
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233
dbId	1173211
disease	[Disease:1247848] non-small cell lung carcinoma
displayName	p-6Y-EGFR L858R [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[ModifiedResidue:179797] O4'-phospho-L-tyrosine at 1092 [ModifiedResidue:179844] O4'-phospho-L-tyrosine at 1172 [ModifiedResidue:179872] O4'-phospho-L-tyrosine at 1197 [ModifiedResidue:179834] O4'-phospho-L-tyrosine at 1110 [ModifiedResidue:180321] O4'-phospho-L-tyrosine at 1016 [ModifiedResidue:182927] O4'-phospho-L-tyrosine at 1069 [ReplacedResidue:1173209] L-leucine 858 replaced with L-arginine
inDisease	true
literatureReference	[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
maxDepth	1
memberOf	[CandidateSet:R-HSA-1182977] Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	p-6Y-EGFR L858R Phosphorylated Epidermal Growth Factor Receptor L858R p-6Y-EGFR Leu858Arg
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1173211
startCoordinate	25
updateTrackers	[UpdateTracker:9888074] Update Tracker - [EntityWithAccessionedSequence:1173211] p-6Y-EGFR L858R [plasma membrane] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9888074] Update Tracker - [EntityWithAccessionedSequence:1173211] p-6Y-EGFR L858R [plasma membrane] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-1182977] Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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