Reactome | Ubiquitinated IkB is degraded

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Ubiquitinated IkB is degraded Show undefined attributes

authored	[InstanceEdit:1168382] May, B, 2010-12-18
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1168634] May, B, 2011-01-03
dbId	1168640
displayName	Ubiquitinated IkB is degraded
edited	[InstanceEdit:1168382] May, B, 2010-12-18
eventOf	[Pathway:R-HSA-1169091] Activation of NF-kappaB in B cells - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1168633] NF-kappaB translocates from the cytosol to the nucleus - Homo sapiens
input	[DefinedSet:R-HSA-1168613] NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169584] Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway [LiteratureReference:1169570] Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B [LiteratureReference:1169546] Inactivation of NF-kappa B inhibitor I kappa B alpha: ubiquitin-dependent proteolysis and its degradation product [LiteratureReference:1169520] Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B [LiteratureReference:1169573] Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B [LiteratureReference:1168544] Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination [LiteratureReference:1169542] A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B [LiteratureReference:208326] Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Ubiquitinated IkB is degraded
orthologousEvent	[BlackBoxEvent:R-GGA-1168640] Ubiquitinated IkB is degraded - Gallus gallus [BlackBoxEvent:R-DME-1168640] Ubiquitinated IkB is degraded - Drosophila melanogaster [BlackBoxEvent:R-XTR-1168640] Ubiquitinated IkB is degraded - Xenopus tropicalis [BlackBoxEvent:R-DRE-1168640] Ubiquitinated IkB is degraded - Danio rerio [BlackBoxEvent:R-SSC-1168640] Ubiquitinated IkB is degraded - Sus scrofa [BlackBoxEvent:R-BTA-1168640] Ubiquitinated IkB is degraded - Bos taurus [BlackBoxEvent:R-CFA-1168640] Ubiquitinated IkB is degraded - Canis familiaris [BlackBoxEvent:R-RNO-1168640] Ubiquitinated IkB is degraded - Rattus norvegicus [BlackBoxEvent:R-MMU-1168640] Ubiquitinated IkB is degraded - Mus musculus
output	[DefinedSet:R-HSA-1168598] NF-kappaB p50,p65,c-Rel dimer [cytosol] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-1168643] SCF-beta-TrCP ubiquitinylates IkB - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11 [InstanceEdit:9954766] May, Bruce, 2025-06-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1168640
summation	[Summation:1169568] Phosphorylated, ubiquitinated IkB is degraded by the proteas...
updateTrackers	[UpdateTracker:9964776] Update Tracker - [BlackBoxEvent:1168640] Ubiquitinated IkB is degraded - v94:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9964776] Update Tracker - [BlackBoxEvent:1168640] Ubiquitinated IkB is degraded - v94:[removeOutput]
(hasEvent)	[Pathway:R-HSA-1169091] Activation of NF-kappaB in B cells
(precedingEvent)	[BlackBoxEvent:R-HSA-1168633] NF-kappaB translocates from the cytosol to the nucleus

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