Reactome | Ubiquitinated IkB is degraded

Ubiquitinated IkB is degraded

Stable Identifier

R-HSA-1168640

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylated, ubiquitinated IkB is degraded by the proteasome (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). IkB does not dissociate from NF-kB before it is proteolyzed (Miyamoto et al. 1994, Traenckner et al. 1994, DiDonato et al. 1995, Lin et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7575604	Inactivation of NF-kappa B inhibitor I kappa B alpha: ubiquitin-dependent proteolysis and its degradation product Li, CC, Dai, RM, Longo, DL	Biochem Biophys Res Commun	1995
7957109	A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B Traenckner, EB, Wilk, S, Baeuerle, PA	EMBO J	1994
7628694	Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway Chen, Z, Hagler, J, Palombella, VJ, Melandri, F, Scherer, D, Ballard, D, Maniatis, T	Genes Dev	1995
7809113	Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B Miyamoto, S, Maki, M, Schmitt, MJ, Hatanaka, M, Verma, IM	Proc Natl Acad Sci U S A	1994
7862124	Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B DiDonato, JA, Mercurio, F, Karin, M	Mol Cell Biol	1995
7479976	Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination Scherer, DC, Brockman, JA, Chen, Z, Maniatis, T, Ballard, DW	Proc Natl Acad Sci U S A	1995
7831327	Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B Lin, YC, Brown, K, Siebenlist, U	Proc Natl Acad Sci U S A	1995
7479848	Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway Alkalay, I, Yaron, A, Hatzubai, A, Orian, A, Ciechanover, A, Ben-Neriah, Y	Proc Natl Acad Sci U S A	1995