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Reaction
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Entries
Activated thrombin (factor IIa) cleaves PAR3,4, activating them
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authored
[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
catalystActivity
[CatalystActivity:139890] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
category
transition
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
dbId
114697
displayName
Activated thrombin (factor IIa) cleaves PAR3,4, activating them
edited
[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
eventOf
[Pathway:R-HSA-456926] Thrombin signalling through proteinase activated receptors (PARs) - Homo sapiens
followingEvent
[Reaction:R-HSA-418091] F2R binds ARRB1 - Homo sapiens
[Reaction:R-HSA-418172] F2R binds ARRB2 - Homo sapiens
[Reaction:R-HSA-396996] Thrombin-activated PARs binds G-protein Gq - Homo sapiens
[Reaction:R-HSA-396941] Thrombin-activated PARs binds G-protein G12/13 - Homo sapiens
input
[DefinedSet:R-HSA-453302] PAR3, 4 [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:140151] Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
[LiteratureReference:140157] Protease-activated receptor 3 is a second thrombin receptor in humans
[LiteratureReference:140075] Cloning and characterization of human protease-activated receptor 4
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
Activated thrombin (factor IIa) cleaves PAR3,4, activating them
Thrombin-mediated activation of Proteinase-activated receptors
orthologousEvent
[Reaction:R-GGA-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Gallus gallus
[Reaction:R-XTR-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Xenopus tropicalis
[Reaction:R-DRE-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Danio rerio
[Reaction:R-SSC-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Sus scrofa
[Reaction:R-BTA-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Bos taurus
[Reaction:R-CFA-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Canis familiaris
[Reaction:R-RNO-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Rattus norvegicus
[Reaction:R-MMU-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Mus musculus
output
[DefinedSet:R-HSA-453303] PAR N-teminal fragments [extracellular region]
[DefinedSet:R-HSA-114530] Thrombin-activated PARs [plasma membrane]
releaseDate
2004-07-06
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-114697
summation
[Summation:397907] Thrombin signaling is mediated at least in part by a small f...
updateTrackers
[UpdateTracker:9791508] Update Tracker - [Reaction:114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - v29:[add_removeOutput]
[UpdateTracker:9790887] Update Tracker - [Reaction:114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]
[UpdateTracker:9791445] Update Tracker - [Reaction:114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - v30:[add_removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9791508] Update Tracker - [Reaction:114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - v29:[add_removeOutput]
[UpdateTracker:9790887] Update Tracker - [Reaction:114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]
[UpdateTracker:9791445] Update Tracker - [Reaction:114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - v30:[add_removeOutput]
(precedingEvent)
[Reaction:R-HSA-418091] F2R binds ARRB1
[Reaction:R-HSA-418172] F2R binds ARRB2
[Reaction:R-HSA-396996] Thrombin-activated PARs binds G-protein Gq
[Reaction:R-HSA-396941] Thrombin-activated PARs binds G-protein G12/13
(hasEvent)
[Pathway:R-HSA-456926] Thrombin signalling through proteinase activated receptors (PARs)
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