Reactome | Activated thrombin (factor IIa) cleaves PAR3,4, activating them

Schema > Reaction > Entries

Activated thrombin (factor IIa) cleaves PAR3,4, activating them Show undefined attributes

catalystActivity	[CatalystActivity:10235042] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10235044
displayName	Activated thrombin (factor IIa) cleaves PAR3,4, activating them
eventOf	[Pathway:R-CFA-456926] Thrombin signalling through proteinase activated receptors (PARs) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-418091] F2R binds ARRB1 - Canis familiaris [Reaction:R-CFA-418172] F2R binds ARRB2 - Canis familiaris [Reaction:R-CFA-396996] Thrombin-activated PARs binds G-protein Gq - Canis familiaris
inferredFrom	[Reaction:R-HSA-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Homo sapiens
input	[DefinedSet:R-CFA-453302] PAR3, 4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated thrombin (factor IIa) cleaves PAR3,4, activating them Thrombin-mediated activation of Proteinase-activated receptors
output	[DefinedSet:R-CFA-453303] PAR N-teminal fragments [extracellular region] [DefinedSet:R-CFA-114530] Thrombin-activated PARs [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-114697
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-456926] Thrombin signalling through proteinase activated receptors (PARs)
(precedingEvent)	[Reaction:R-CFA-418091] F2R binds ARRB1 [Reaction:R-CFA-418172] F2R binds ARRB2 [Reaction:R-CFA-396996] Thrombin-activated PARs binds G-protein Gq
(inferredTo)	[Reaction:R-HSA-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them

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