Reactome | Adhesion of integrin ?IIb?3 to fibrin network

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Adhesion of integrin ?IIb?3 to fibrin network Show undefined attributes

authored	[InstanceEdit:266384] Geiger, B, Horwitz, R, 2008-05-07 08:30:32
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
dbId	114560
displayName	Adhesion of integrin ?IIb?3 to fibrin network
eventOf	[Pathway:R-HSA-9769733] Fibrin formation - Homo sapiens [Pathway:R-HSA-216083] Integrin cell surface interactions - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9921091] ?IIb?3:fibrin multimer ->?IIb?3:fibrin multimer, crosslinked + NH4+ - Homo sapiens
input	[Complex:R-HSA-139933] fibrin multimer [extracellular region] [Complex:R-HSA-114514] Integrin alphaIIb:beta3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140237] Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways [LiteratureReference:9921030] The Platelet Integrin ?IIb?3 Differentially Interacts with Fibrin Versus Fibrinogen [LiteratureReference:9921036] The interaction of integrin ?IIb?3 with fibrin occurs through multiple binding sites in the ?IIb ?-propeller domain [LiteratureReference:9921045] Structural basis for distinctive recognition of fibrinogen gammaC peptide by the platelet integrin alphaIIbbeta3 [LiteratureReference:9921070] The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand [LiteratureReference:9921084] Strong Binding of Platelet Integrin ?IIb?3 to Fibrin Clots: Potential Target to Destabilize Thrombi
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Adhesion of integrin ?IIb?3 to fibrin network
orthologousEvent	[Reaction:R-DRE-114560] Adhesion of integrin ?IIb?3 to fibrin network - Danio rerio [Reaction:R-SSC-114560] Adhesion of integrin ?IIb?3 to fibrin network - Sus scrofa [Reaction:R-RNO-114560] Adhesion of integrin ?IIb?3 to fibrin network - Rattus norvegicus [Reaction:R-MMU-114560] Adhesion of integrin ?IIb?3 to fibrin network - Mus musculus
output	[Complex:R-HSA-114559] Integrin alpha IIb beta 3:fibrin multimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-140842] n fibrin monomers -> fibrin multimer - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:266386] Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-114560
summation	[Summation:178451] This Reactome event shows binding of the platelet glycoprote...
updateTrackers	[UpdateTracker:9928516] Update Tracker - [Reaction:114560] Adhesion of integrin ?IIb?3 to fibrin network - v91:[modifyText, removeLiteratureReference] [UpdateTracker:9939774] Update Tracker - [Reaction:114560] Adhesion of integrin ?IIb?3 to fibrin network - v92:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9928516] Update Tracker - [Reaction:114560] Adhesion of integrin ?IIb?3 to fibrin network - v91:[modifyText, removeLiteratureReference] [UpdateTracker:9939774] Update Tracker - [Reaction:114560] Adhesion of integrin ?IIb?3 to fibrin network - v92:[modifyText]
(precedingEvent)	[BlackBoxEvent:R-HSA-9921091] ?IIb?3:fibrin multimer ->?IIb?3:fibrin multimer, crosslinked + NH4+
(hasEvent)	[Pathway:R-HSA-9769733] Fibrin formation [Pathway:R-HSA-216083] Integrin cell surface interactions

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