Reactome | PKC phosphorylates GRK2

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PKC phosphorylates GRK2 Show undefined attributes

authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity	[CatalystActivity:111967] protein serine/threonine kinase activity of active PKC (alpha, gamma, delta) [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:111947] Schmidt, EE, 2004-03-26 09:35:25
dbId	111970
displayName	PKC phosphorylates GRK2
eventOf	[Pathway:R-HSA-111933] Calmodulin induced events - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-50270] GRK2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111971] Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PKC phosphorylates GRK2
orthologousEvent	[Reaction:R-RNO-111970] PKC phosphorylates GRK2 - Rattus norvegicus [Reaction:R-CEL-111970] PKC phosphorylates GRK2 - Caenorhabditis elegans [Reaction:R-DME-111970] PKC phosphorylates GRK2 - Drosophila melanogaster [Reaction:R-GGA-111970] PKC phosphorylates GRK2 - Gallus gallus [Reaction:R-XTR-111970] PKC phosphorylates GRK2 - Xenopus tropicalis [Reaction:R-DRE-111970] PKC phosphorylates GRK2 - Danio rerio [Reaction:R-SSC-111970] PKC phosphorylates GRK2 - Sus scrofa [Reaction:R-BTA-111970] PKC phosphorylates GRK2 - Bos taurus [Reaction:R-CFA-111970] PKC phosphorylates GRK2 - Canis familiaris [Reaction:R-MMU-111970] PKC phosphorylates GRK2 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-111969] p-S29-ADRBK1 [plasma membrane]
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-111970
summation	[Summation:1986604] ADRBK1 (also known as GRK2) is phosphorylated at serine 29 i...
updateTrackers	[UpdateTracker:9789006] Update Tracker - [Reaction:111970] PKC phosphorylates GRK2 - v39:[addSummation] [UpdateTracker:9782555] Update Tracker - [Reaction:111970] PKC phosphorylates GRK2 - v59:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789006] Update Tracker - [Reaction:111970] PKC phosphorylates GRK2 - v39:[addSummation] [UpdateTracker:9782555] Update Tracker - [Reaction:111970] PKC phosphorylates GRK2 - v59:[modifyText]
(hasEvent)	[Pathway:R-HSA-111933] Calmodulin induced events