Reactome | GRK2 binds CALM1:4Ca2+

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GRK2 binds CALM1:4Ca2+ Show undefined attributes

authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:111947] Schmidt, EE, 2004-03-26 09:35:25
dbId	111966
displayName	GRK2 binds CALM1:4Ca2+
edited	[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
eventOf	[Pathway:R-HSA-111933] Calmodulin induced events - Homo sapiens
input	[Complex:R-HSA-74294] CALM1:4xCa2+ [cytosol] [EntityWithAccessionedSequence:R-HSA-50270] GRK2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111973] Inhibition of G protein-coupled receptor kinase subtypes by Ca2+/calmodulin. [LiteratureReference:111971] Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin. [LiteratureReference:379909] Localization of the sites for Ca2+-binding proteins on G protein-coupled receptor kinases
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GRK2 binds CALM1:4Ca2+ Inhibition of ADRBK2 by calmodulin
orthologousEvent	[Reaction:R-RNO-111966] GRK2 binds CALM1:4Ca2+ - Rattus norvegicus [Reaction:R-CEL-111966] GRK2 binds CALM1:4Ca2+ - Caenorhabditis elegans [Reaction:R-DME-111966] GRK2 binds CALM1:4Ca2+ - Drosophila melanogaster [Reaction:R-BTA-111966] GRK2 binds CALM1:4Ca2+ - Bos taurus [Reaction:R-CFA-111966] GRK2 binds CALM1:4Ca2+ - Canis familiaris [Reaction:R-MMU-111966] GRK2 binds CALM1:4Ca2+ - Mus musculus
output	[Complex:R-HSA-111965] GRK2:CALM1:4xCa2+ [plasma membrane]
precedingEvent	[Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-111972] Negative regulation by 'active PKC (alpha, gamma, delta) [cytosol]'
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-111966
summation	[Summation:379914] ADRBK1 (also known as GRK2) is a Serine/Threonine kinase. G-...
updateTrackers	[UpdateTracker:9790629] Update Tracker - [Reaction:111966] GRK2 binds CALM1:4Ca2+ - v33:[addInput] [UpdateTracker:9780556] Update Tracker - [Reaction:111966] GRK2 binds CALM1:4Ca2+ - v62:[add_removeInput] [UpdateTracker:9782291] Update Tracker - [Reaction:111966] GRK2 binds CALM1:4Ca2+ - v59:[add_removeRegulator, modifyText] [UpdateTracker:9777699] Update Tracker - [Reaction:111966] GRK2 binds CALM1:4Ca2+ - v69:[add_removeInput]

Referrals

(updatedInstance)

[UpdateTracker:9790629] Update Tracker - [Reaction:111966] GRK2 binds CALM1:4Ca2+ - v33:[addInput]
[UpdateTracker:9780556] Update Tracker - [Reaction:111966] GRK2 binds CALM1:4Ca2+ - v62:[add_removeInput]
[UpdateTracker:9782291] Update Tracker - [Reaction:111966] GRK2 binds CALM1:4Ca2+ - v59:[add_removeRegulator, modifyText]
[UpdateTracker:9777699] Update Tracker - [Reaction:111966] GRK2 binds CALM1:4Ca2+ - v69:[add_removeInput]

(hasEvent)

[Pathway:R-HSA-111933] Calmodulin induced events

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