ADRBK1 (also known as GRK2) is a Serine/Threonine kinase. G-protein-coupled receptor kinases (GRKs) are important regulators of G-protein-coupled receptor function. Binding of calmodulin to ADRBK1 results in inhibition of the kinase activity. This inhibition is almost completely abolished when ADRBK1 is phosphorylated by PKC.
Paolucci, L, De Blasi, A, Chuang, TT
Dammeier, S, Winstel, R, Krasel, C, Lohse, MJ, Brockmann, J, Mischak, H
Slepak, VZ, Pronin, AN, Satpaev, DK, Benovic, JL, Levay, K
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