GRK2 binds CALM1:4Ca2+

Stable Identifier
R-HSA-111966
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
Inhibition of ADRBK2 by calmodulin
ReviewStatus
5/5
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GRK2 binds CALM1:4Ca2+
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ADRBK1 (also known as GRK2) is a Serine/Threonine kinase. G-protein-coupled receptor kinases (GRKs) are important regulators of G-protein-coupled receptor function. Binding of calmodulin to ADRBK1 results in inhibition of the kinase activity. This inhibition is almost completely abolished when ADRBK1 is phosphorylated by PKC.
Literature References
PubMed ID Title Journal Year
8910504 Inhibition of G protein-coupled receptor kinase subtypes by Ca2+/calmodulin.

Paolucci, L, De Blasi, A, Chuang, TT

J Biol Chem 1996
11042191 Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.

Dammeier, S, Winstel, R, Krasel, C, Lohse, MJ, Brockmann, J, Mischak, H

J Biol Chem 2001
9753452 Localization of the sites for Ca2+-binding proteins on G protein-coupled receptor kinases

Slepak, VZ, Pronin, AN, Satpaev, DK, Benovic, JL, Levay, K

Biochemistry 1998
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
active PKC (alpha, gamma, delta) [cytosol] (Homo sapiens)
Orthologous Events
GRK2 binds CALM1:4Ca2+ (Bos taurus)
GRK2 binds CALM1:4Ca2+ (Caenorhabditis elegans)
GRK2 binds CALM1:4Ca2+ (Canis familiaris)
GRK2 binds CALM1:4Ca2+ (Drosophila melanogaster)
GRK2 binds CALM1:4Ca2+ (Gallus gallus)
GRK2 binds CALM1:4Ca2+ (Mus musculus)
GRK2 binds CALM1:4Ca2+ (Rattus norvegicus)
GRK2 binds CALM1:4Ca2+ (Sus scrofa)
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Schmidt, EE  (2004-03-26)
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