GRK2 binds CALM1:4Ca2+

Stable Identifier
R-HSA-111966
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Inhibition of ADRBK2 by calmodulin
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ADRBK1 (also known as GRK2) is a Serine/Threonine kinase. G-protein-coupled receptor kinases (GRKs) are important regulators of G-protein-coupled receptor function. Binding of calmodulin to ADRBK1 results in inhibition of the kinase activity. This inhibition is almost completely abolished when ADRBK1 is phosphorylated by PKC.

Literature References
PubMed ID Title Journal Year
11042191 Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.

Krasel, C, Dammeier, S, Winstel, R, Brockmann, J, Mischak, H, Lohse, MJ

J Biol Chem 2001
8910504 Inhibition of G protein-coupled receptor kinase subtypes by Ca2+/calmodulin.

Chuang, TT, Paolucci, L, De Blasi, A

J Biol Chem 1996
9753452 Localization of the sites for Ca2+-binding proteins on G protein-coupled receptor kinases

Levay, K, Satpaev, DK, Pronin, AN, Benovic, JL, Slepak, VZ

Biochemistry 1998
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