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Schema
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Reaction
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Entries
Cleavage of dihydrouracil by NTHL1 glycosylase
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authored
[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity
[CatalystActivity:5643996] oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity of NTHL1:DHU-dsDNA [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
dbId
110227
diseaseReaction
[FailedReaction:R-HSA-9630055] NTHL1 D239Y does not cleave dihydrouracil (DHU) - Homo sapiens
displayName
Cleavage of dihydrouracil by NTHL1 glycosylase
edited
[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf
[Pathway:R-HSA-110329] Cleavage of the damaged pyrimidine - Homo sapiens
followingEvent
[Reaction:R-HSA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site - Homo sapiens
input
[Complex:R-HSA-110181] NTHL1:DHU-dsDNA [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5637569] Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue
[LiteratureReference:5637590] Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
Cleavage of dihydrouracil by NTHL1 glycosylase
orthologousEvent
[Reaction:R-PFA-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Plasmodium falciparum
[Reaction:R-SCE-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Saccharomyces cerevisiae
[Reaction:R-SPO-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Schizosaccharomyces pombe
[Reaction:R-DDI-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Dictyostelium discoideum
[Reaction:R-CEL-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Caenorhabditis elegans
[Reaction:R-DME-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Drosophila melanogaster
[Reaction:R-GGA-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Gallus gallus
[Reaction:R-XTR-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Xenopus tropicalis
[Reaction:R-DRE-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Danio rerio
[Reaction:R-SSC-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Sus scrofa
[Reaction:R-BTA-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Bos taurus
[Reaction:R-CFA-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Canis familiaris
[Reaction:R-RNO-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Rattus norvegicus
[Reaction:R-MMU-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Mus musculus
output
[SimpleEntity:R-ALL-30140] DHU [nucleoplasm]
[Complex:R-HSA-110193] NTHL1:AP-dsDNA [nucleoplasm]
precedingEvent
[Reaction:R-HSA-110212] NTHL1 glycosylase mediated recognition and binding of dihydrouracil - Homo sapiens
releaseDate
2004-03-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5673689] Borowiec, James, 2014-12-22
revised
[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-110227
summation
[Summation:178543] NTHL1 (hNTH1; endonuclease III-like protein 1) acts as a DNA...
updateTrackers
[UpdateTracker:9785411] Update Tracker - [Reaction:110227] Cleavage of dihydrouracil by NTHL1 glycosylase - v52:[add_removeCatalystActivity, modifyText]
[UpdateTracker:9785883] Update Tracker - [Reaction:110227] Cleavage of dihydrouracil by NTHL1 glycosylase - v51:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9785411] Update Tracker - [Reaction:110227] Cleavage of dihydrouracil by NTHL1 glycosylase - v52:[add_removeCatalystActivity, modifyText]
[UpdateTracker:9785883] Update Tracker - [Reaction:110227] Cleavage of dihydrouracil by NTHL1 glycosylase - v51:[addLiteratureReference, modifyText]
(normalReaction)
[FailedReaction:R-HSA-9630055] NTHL1 D239Y does not cleave dihydrouracil (DHU)
(precedingEvent)
[Reaction:R-HSA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site
(hasEvent)
[Pathway:R-HSA-110329] Cleavage of the damaged pyrimidine
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