Cleavage of dihydrouracil by NTHL1 glycosylase

Stable Identifier
R-HSA-110227
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NTHL1 (hNTH1; endonuclease III-like protein 1) acts as a DNA glycosylase to cleave 5,6-dihydrouracil, formed by deamination of cytosine with partial saturation of the pyrimidine ring (Dizdaroglu et al. 1993), from the DNA sugar-phosphate backbone, and leaves an apurinic/apyrimidinic (AP) site. After the AP site is created, NTHL1 acts as a beta lyase to cleave the DNA strand 5' to the AP site (Ikeda et al. 1998).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity of NTHL1:DHU-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created