Reactome | Cleavage of uracil by UNG glycosylase

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Cleavage of uracil by UNG glycosylase Show undefined attributes

authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5649475] uracil DNA N-glycosylase activity of UNG-1:(Ura:Gua)-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
dbId	110215
displayName	Cleavage of uracil by UNG glycosylase
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-110329] Cleavage of the damaged pyrimidine - Homo sapiens
followingEvent	[Reaction:R-HSA-110349] Displacement of UNG glycosylase by APEX1 at the AP site - Homo sapiens
input	[Complex:R-HSA-110152] UNG-1:(Ura:Gua)-dsDNA [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111242] Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Cleavage of uracil by UNG glycosylase
orthologousEvent	[Reaction:R-PFA-110215] Cleavage of uracil by UNG glycosylase - Plasmodium falciparum [Reaction:R-SCE-110215] Cleavage of uracil by UNG glycosylase - Saccharomyces cerevisiae [Reaction:R-SPO-110215] Cleavage of uracil by UNG glycosylase - Schizosaccharomyces pombe [Reaction:R-DDI-110215] Cleavage of uracil by UNG glycosylase - Dictyostelium discoideum [Reaction:R-GGA-110215] Cleavage of uracil by UNG glycosylase - Gallus gallus [Reaction:R-XTR-110215] Cleavage of uracil by UNG glycosylase - Xenopus tropicalis [Reaction:R-DRE-110215] Cleavage of uracil by UNG glycosylase - Danio rerio [Reaction:R-SSC-110215] Cleavage of uracil by UNG glycosylase - Sus scrofa [Reaction:R-CFA-110215] Cleavage of uracil by UNG glycosylase - Canis familiaris [Reaction:R-RNO-110215] Cleavage of uracil by UNG glycosylase - Rattus norvegicus [Reaction:R-MMU-110215] Cleavage of uracil by UNG glycosylase - Mus musculus
output	[Complex:R-HSA-110188] UNG-1:AP-dsDNA [nucleoplasm] [SimpleEntity:R-ALL-29554] Ura [nucleoplasm]
precedingEvent	[Reaction:R-HSA-110156] UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-110215
summation	[Summation:178555] UNG, a DNA uracil glycosylase, excises the uracil base gener...
updateTrackers	[UpdateTracker:9785688] Update Tracker - [Reaction:110215] Cleavage of uracil by UNG glycosylase - v51:[add_removeLiteratureReference, modifyText] [UpdateTracker:9785253] Update Tracker - [Reaction:110215] Cleavage of uracil by UNG glycosylase - v52:[add_removeCatalystActivity, modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9785688] Update Tracker - [Reaction:110215] Cleavage of uracil by UNG glycosylase - v51:[add_removeLiteratureReference, modifyText] [UpdateTracker:9785253] Update Tracker - [Reaction:110215] Cleavage of uracil by UNG glycosylase - v52:[add_removeCatalystActivity, modifyText, removeLiteratureReference]
(precedingEvent)	[Reaction:R-HSA-110349] Displacement of UNG glycosylase by APEX1 at the AP site
(hasEvent)	[Pathway:R-HSA-110329] Cleavage of the damaged pyrimidine

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