Reactome | AMP + ATP <=> ADP + ADP [AK2]

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AMP + ATP <=> ADP + ADP [AK2] Show undefined attributes

catalystActivity	[CatalystActivity:110089] AMP kinase activity of AK2 [mitochondrial intermembrane space]
catalystActivityReference	[CatalystActivityReference:9643852] adenylate kinase activity of AK2 [mitochondrial intermembrane space] Adenosine triphosphate-adenosine-5'-monophosphate phosphotransferase from normal human liver mitochondria. Isolation, chemical properties, and immunochemical comparison with Duchenne muscular dystrophic serum aberrant adenylate kinase
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:110076] D'Eustachio, P, 2004-01-28 17:55:00
crossReference	[DatabaseIdentifier:12668015] RHEA:12974 [DatabaseIdentifier:9975771] RHEA:12974
dbId	110145
deleted	[Deleted:500085] Deletion of instance: 110131
displayName	AMP + ATP <=> ADP + ADP [AK2]
eventOf	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
input	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:110124] Rat liver adenosine triphosphate:adenosine monophosphate phosphotransferase activity. II. Subcellular localization of adenylate kinase isozymes [LiteratureReference:110081] Adenosine triphosphate-adenosine-5'-monophosphate phosphotransferase from normal human liver mitochondria. Isolation, chemical properties, and immunochemical comparison with Duchenne muscular dystrophic serum aberrant adenylate kinase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	AMP + ATP <=> ADP + ADP [AK2] AMP + ATP => 2 ADP
orthologousEvent	[Reaction:R-PFA-110145] AMP + ATP <=> ADP + ADP [AK2] - Plasmodium falciparum [Reaction:R-SCE-110145] AMP + ATP <=> ADP + ADP [AK2] - Saccharomyces cerevisiae [Reaction:R-SPO-110145] AMP + ATP <=> ADP + ADP [AK2] - Schizosaccharomyces pombe [Reaction:R-DDI-110145] AMP + ATP <=> ADP + ADP [AK2] - Dictyostelium discoideum [Reaction:R-CEL-110145] AMP + ATP <=> ADP + ADP [AK2] - Caenorhabditis elegans [Reaction:R-DME-110145] AMP + ATP <=> ADP + ADP [AK2] - Drosophila melanogaster [Reaction:R-GGA-110145] AMP + ATP <=> ADP + ADP [AK2] - Gallus gallus [Reaction:R-XTR-110145] AMP + ATP <=> ADP + ADP [AK2] - Xenopus tropicalis [Reaction:R-DRE-110145] AMP + ATP <=> ADP + ADP [AK2] - Danio rerio [Reaction:R-SSC-110145] AMP + ATP <=> ADP + ADP [AK2] - Sus scrofa [Reaction:R-BTA-110145] AMP + ATP <=> ADP + ADP [AK2] - Bos taurus [Reaction:R-CFA-110145] AMP + ATP <=> ADP + ADP [AK2] - Canis familiaris [Reaction:R-RNO-110145] AMP + ATP <=> ADP + ADP [AK2] - Rattus norvegicus [Reaction:R-MMU-110145] AMP + ATP <=> ADP + ADP [AK2] - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-110144] ADP + ADP <=> AMP + ATP [AK2]
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-110145
summation	[Summation:178436] Mitochondrial adenylate kinase 2 (AK2) catalyzes the reactio...
updateTrackers	[UpdateTracker:9790994] Update Tracker - [Reaction:110145] AMP + ATP <=> ADP + ADP [AK2] - v32:[addLiteratureReference, modifyText] [UpdateTracker:9790149] Update Tracker - [Reaction:110145] AMP + ATP <=> ADP + ADP [AK2] - v35:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790994] Update Tracker - [Reaction:110145] AMP + ATP <=> ADP + ADP [AK2] - v32:[addLiteratureReference, modifyText] [UpdateTracker:9790149] Update Tracker - [Reaction:110145] AMP + ATP <=> ADP + ADP [AK2] - v35:[modifyText]
(replacementInstances)	[Deleted:500085] Deletion of instance: 110131
(hasEvent)	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates

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