AMP + ATP <=> ADP + ADP [AK2]

Stable Identifier
R-HSA-110145
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial intermembrane space
ReviewStatus
5/5
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AMP + ATP <=> ADP + ADP [AK2]
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Mitochondrial adenylate kinase 2 (AK2) catalyzes the reaction of AMP and ATP to form two molecules of ADP (Hamade et al. 1982). Localization of AK2 specifically to the mitochondrial intermembrane space is inferred from studies of the homologous rat enzyme (Criss 1970).
Literature References
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Event Information
Reverse Reaction
ADP + ADP <=> AMP + ATP [AK2] (Homo sapiens)
Catalyst Activity

AMP kinase activity of AK2 [mitochondrial intermembrane space]

Physical Entity
AK2 [mitochondrial intermembrane space] (Homo sapiens)
Activity
AMP kinase activity (GO:0004017)
Orthologous Events
AMP + ATP <=> ADP + ADP [AK2] (Bos taurus)
AMP + ATP <=> ADP + ADP [AK2] (Caenorhabditis elegans)
AMP + ATP <=> ADP + ADP [AK2] (Canis familiaris)
AMP + ATP <=> ADP + ADP [AK2] (Danio rerio)
AMP + ATP <=> ADP + ADP [AK2] (Dictyostelium discoideum)
AMP + ATP <=> ADP + ADP [AK2] (Drosophila melanogaster)
AMP + ATP <=> ADP + ADP [AK2] (Gallus gallus)
AMP + ATP <=> ADP + ADP [AK2] (Mus musculus)
AMP + ATP <=> ADP + ADP [AK2] (Plasmodium falciparum)
AMP + ATP <=> ADP + ADP [AK2] (Rattus norvegicus)
AMP + ATP <=> ADP + ADP [AK2] (Saccharomyces cerevisiae)
AMP + ATP <=> ADP + ADP [AK2] (Schizosaccharomyces pombe)
AMP + ATP <=> ADP + ADP [AK2] (Sus scrofa)
AMP + ATP <=> ADP + ADP [AK2] (Xenopus tropicalis)
Cross References
RHEA
Created
D'Eustachio, P  (2004-01-28)
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