Reactome | Negative regulation by 'GRB10:INSR [plasma membrane]'

Schema > NegativeRegulation > Entries

activeUnit	[EntityWithAccessionedSequence:R-HSA-110009] GRB10 [cytosol] - Homo sapiens
created	[InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12
dbId	110016
displayName	Negative regulation by 'GRB10:INSR [plasma membrane]'
modified	[InstanceEdit:9608020] Wu, G, 2018-05-08
regulatedEntity	[Reaction:R-HSA-74707] Binding of IRS to insulin receptor - Homo sapiens
regulator	[Complex:R-HSA-110010] GRB10:INSR [plasma membrane]
schemaClass	NegativeRegulation
stId	R-HSA-110016

(regulation)	[RegulationReference:9642069] Negative regulation by 'GRB10:INSR [plasma membrane]' Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
(regulatedBy)	[Reaction:R-HSA-74707] Binding of IRS to insulin receptor

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