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Schema
>
Reaction
>
Entries
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]
Show undefined attributes
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catalystActivity
[CatalystActivity:109900] nucleoside kinase activity of UCK2 tetramer [cytosol]
catalystActivityReference
[CatalystActivityReference:9643215] nucleoside kinase activity of UCK2 tetramer [cytosol] Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:109881] D'Eustachio, P, 2004-01-21 17:18:00
crossReference
[DatabaseIdentifier:9976243] RHEA:24675
[DatabaseIdentifier:9976249] RHEA:16826
dbId
109903
deleted
[Deleted:500804] Deletion of instances: 109904, 109901
displayName
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]
eventOf
[Pathway:R-HSA-73614] Pyrimidine salvage - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[DefinedSet:R-ALL-500759] Cyt-Rib, Ura-Rib [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:109887] Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma
[LiteratureReference:500798] Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase
[LiteratureReference:109895] Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases
[LiteratureReference:109899] Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
maxDepth
1
modified
[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]
cytidine + ATP => CMP + ADP + H(+)
uridine + ATP => UMP + ADP + H(+)
orthologousEvent
[Reaction:R-MMU-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Mus musculus
[Reaction:R-DDI-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Dictyostelium discoideum
[Reaction:R-CEL-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Caenorhabditis elegans
[Reaction:R-DME-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Drosophila melanogaster
[Reaction:R-GGA-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Gallus gallus
[Reaction:R-XTR-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Xenopus tropicalis
[Reaction:R-DRE-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Danio rerio
[Reaction:R-SSC-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Sus scrofa
[Reaction:R-BTA-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Bos taurus
[Reaction:R-CFA-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Canis familiaris
[Reaction:R-RNO-109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - Rattus norvegicus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[DefinedSet:R-ALL-500761] CMP, UMP [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2004-07-06
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
revised
[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-109903
summation
[Summation:178597] Cytosolic uridine-cytidine kinase 2 (UCK2) catalyzes the rea...
updateTrackers
[UpdateTracker:9790893] Update Tracker - [Reaction:109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9984644] Update Tracker - [Reaction:109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - v96:[removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9790893] Update Tracker - [Reaction:109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9984644] Update Tracker - [Reaction:109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - v96:[removeOutput]
(replacementInstances)
[Deleted:500804] Deletion of instances: 109904, 109901
(hasEvent)
[Pathway:R-HSA-73614] Pyrimidine salvage
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