Cytosolic uridine-cytidine kinase 2 (UCK2) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Crystallographic data show the enzyme to be a tetramer (Suzuki et al. 2004). When it is expressed as a fusion construct with green fluorescent protein, the protein localizes primarily to the cytosol of transfected CHO cells (Van Rompay et al. 2003).
Webb, TE, Greenberg, N, Schumm, DE
Van Rompay, AR, Karlsson, A, Johansson, M
Matsuda, A, Suzuki, NN, Inagaki, F, Koizumi, K, Fukushima, M
Linden, K, Van Rompay, AR, Norda, A, Karlsson, A, Johansson, M
nucleoside kinase activity of UCK2 tetramer [cytosol]
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