Reactome | (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)

Schema > Reaction > Entries

(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) Show undefined attributes

catalystActivity	[CatalystActivity:109469] 5'-nucleotidase activity of NT5C dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643849] 5'-nucleotidase activity of NT5C dimer [cytosol] Cytoplasmic 5'(3')-nucleotidase from human placenta
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109462] D'Eustachio, P, 2004-01-09 08:30:00
crossReference	[DatabaseIdentifier:12667762] RHEA:27715 [DatabaseIdentifier:9976355] RHEA:27715 [DatabaseIdentifier:9976336] RHEA:29380 [DatabaseIdentifier:9976361] RHEA:27719 [DatabaseIdentifier:9976350] RHEA:29384
dbId	109470
deleted	[Deleted:500130] Deletion of instances: 109483, 109482, 109479 [Deleted:500418] Deletion of instance: 109471
displayName	(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)
eventOf	[Pathway:R-HSA-74259] Purine catabolism - Homo sapiens
input	[DefinedSet:R-ALL-500120] (d)GMP, (d)IMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:109465] Cytoplasmic 5'(3')-nucleotidase from human placenta [LiteratureReference:109348] Cytosolic high Km 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism [LiteratureReference:109473] Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) GMP + H2O => guanosine + phosphate dGMP + H2O => 2'-deoxyguanosine + phosphate IMP + H2O => inosine + phosphate dIMP + H2O => 2'-deoxyinosine + phosphate
orthologousEvent	[Reaction:R-XTR-109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - Xenopus tropicalis [Reaction:R-SSC-109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - Sus scrofa [Reaction:R-BTA-109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - Bos taurus [Reaction:R-CFA-109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - Canis familiaris [Reaction:R-RNO-109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - Rattus norvegicus [Reaction:R-MMU-109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - Mus musculus
output	[DefinedSet:R-ALL-500118] Gu-Rib, dG, Ino, dI [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109470
summation	[Summation:178302] Cytosolic 5'3'-nucleotidase (NT5C) catalyzes the hydrolysis ...
updateTrackers	[UpdateTracker:9790932] Update Tracker - [Reaction:109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790932] Update Tracker - [Reaction:109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(replacementInstances)	[Deleted:500130] Deletion of instances: 109483, 109482, 109479 [Deleted:500418] Deletion of instance: 109471
(hasEvent)	[Pathway:R-HSA-74259] Purine catabolism

Cite Us!