Reactome | ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans

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ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:1022131] beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL4 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:1022125] Jassal, B, 2010-11-17
dbId	1022129
displayName	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans
edited	[InstanceEdit:975912] Jassal, B, 2010-10-08
eventOf	[Pathway:R-HSA-975577] N-Glycan antennae elongation - Homo sapiens
input	[SimpleEntity:R-ALL-975925] Neu5Ac [Golgi lumen] [SimpleEntity:R-ALL-975910] NGP [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1015847] Achievements and challenges of sialic acid research [LiteratureReference:1022100] The human sialyltransferase family [LiteratureReference:1015841] The sialyl-alpha2,6-lactosaminyl-structure: biosynthesis and functional role [LiteratureReference:1015848] Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II [LiteratureReference:1022105] Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands [LiteratureReference:1022101] Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III [LiteratureReference:1022093] Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST [LiteratureReference:422420] Polysialyltransferases: major players in polysialic acid synthesis on the neural cell adhesion molecule
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans Addition of alpha-2,3-sialic acid to N-glycan over a galactose by ST3GAL4
orthologousEvent	[Reaction:R-BTA-1022129] ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans - Bos taurus [Reaction:R-GGA-1022129] ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans - Gallus gallus [Reaction:R-XTR-1022129] ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans - Xenopus tropicalis [Reaction:R-DRE-1022129] ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans - Danio rerio [Reaction:R-SSC-1022129] ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans - Sus scrofa [Reaction:R-CFA-1022129] ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans - Canis familiaris [Reaction:R-RNO-1022129] ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans - Rattus norvegicus [Reaction:R-MMU-1022129] ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans - Mus musculus
output	[OtherEntity:R-ALL-981615] Glycoprotein-Neu5Ac [Golgi lumen]
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1028799] Gagneux, P, 2010-11-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1022129
summation	[Summation:1022130] Addition of sialic acid (Neu5Ac) to galactose-containing N-g...
updateTrackers	[UpdateTracker:9787132] Update Tracker - [Reaction:1022129] ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans - v46:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787132] Update Tracker - [Reaction:1022129] ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans - v46:[modifyText]
(hasEvent)	[Pathway:R-HSA-975577] N-Glycan antennae elongation

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