Reactome | FXIIa activates plasma kallikrein-kinin system

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FXIIa activates plasma kallikrein-kinin system Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10825783
displayName	FXIIa activates plasma kallikrein-kinin system
eventOf	[Pathway:R-GGA-168249] Innate Immune System - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259393] plasma kallikrein-kinin cascade
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-9855705] factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma) - Gallus gallus [Reaction:R-GGA-9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) - Gallus gallus [Reaction:R-GGA-158313] factor XII -> factor XIIa - Gallus gallus [Reaction:R-GGA-9857939] prekallikrein + kininogen -> prekallikrein:kininogen - Gallus gallus [Reaction:R-GGA-9857952] prekallikrein:kininogen binds cell surface receptors - Gallus gallus [Reaction:R-GGA-9855685] factor XII + prekallikrein:kininogen:cell surface receptor -> prekallikrein:kininogen:cell surface receptor:factor XII - Gallus gallus [Reaction:R-GGA-9857814] prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) - Gallus gallus [Reaction:R-GGA-9909048] prekallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor:factor XII (FXII catalyst) - Gallus gallus [Reaction:R-GGA-9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) - Gallus gallus [Reaction:R-GGA-9857945] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst) - Gallus gallus [Reaction:R-GGA-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) - Gallus gallus [Reaction:R-GGA-9938539] kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin - Gallus gallus [Pathway:R-GGA-9855719] Regulation of FXIIa and plasma kallikrein activity - Gallus gallus
inferredFrom	[Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	FXIIa activates plasma kallikrein-kinin system Factor XIIa activates plasma kallikrein-kinin system
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-9970672
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-GGA-9935598] FXIIa, PKa-dependent activation of coagulation pathway
(hasEvent)	[Pathway:R-GGA-168249] Innate Immune System
(inferredTo)	[Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system

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