Reactome | factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis)

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factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) Show undefined attributes

catalystActivity	[CatalystActivity:10822218] serine-type endopeptidase activity of FXII:polyanionic activator [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10822220
displayName	factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis)
eventOf	[Pathway:R-GGA-9970672] FXIIa activates plasma kallikrein-kinin system - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) - Gallus gallus [Reaction:R-GGA-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) - Gallus gallus [Reaction:R-GGA-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Gallus gallus
inferredFrom	[Reaction:R-HSA-9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) - Homo sapiens
input	[Complex:R-GGA-9857879] FXII:polyanionic activator [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) factor XII -> factor XIIa (autocatalysis on polyanionic molecules)
output	[Complex:R-GGA-158306] factor XIIa [extracellular region] [DefinedSet:R-GGA-9855736] polyanionic activators of FXII [extracellular region]
precedingEvent	[Reaction:R-GGA-9855705] factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma) - Gallus gallus
regulatedBy	[Requirement:R-HSA-159017] Requirement by 'Zn2+ [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9855735
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) [Reaction:R-GGA-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) [Reaction:R-GGA-9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst)
(hasEvent)	[Pathway:R-GGA-9970672] FXIIa activates plasma kallikrein-kinin system
(inferredTo)	[Reaction:R-HSA-9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis)

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