Reactome | p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane

Schema > Reaction > Entries

p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10822573
displayName	p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane
eventOf	[Pathway:R-GGA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9865215] p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [Complex:R-GGA-9857675] ITGA5:ITGB1 [plasma membrane] [EntityWithAccessionedSequence:R-GGA-9865163] phospho-ANXA2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane
output	[Complex:R-GGA-9865197] p-S26-ANXA2:ITGA5:ITGB1:Ca2+ [plasma membrane]
precedingEvent	[Reaction:R-GGA-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9865215
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
(inferredTo)	[Reaction:R-HSA-9865215] p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane

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