Reactome | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells

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Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10828193
displayName	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
eventOf	[Pathway:R-GGA-9860931] Response of endothelial cells to shear stress - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8857191] vascular endothelial cell response to oscillatory fluid shear stress
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Gallus gallus [Reaction:R-GGA-9865215] p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane - Gallus gallus [Reaction:R-GGA-9865226] PP2A dephosphorylates serine-127 of YAP1 - Gallus gallus [BlackBoxEvent:R-GGA-9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress - Gallus gallus [Reaction:R-GGA-9865196] p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1 - Gallus gallus [BlackBoxEvent:R-GGA-9865176] p-Y407-YAP1 translocates from the cytosol to the nucleoplasm - Gallus gallus [BlackBoxEvent:R-GGA-9861486] PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus - Gallus gallus [BlackBoxEvent:R-GGA-9865492] Phosphorylation of IKBKE on serine-172 in response to low shear stress - Gallus gallus [BlackBoxEvent:R-GGA-9865511] Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE - Gallus gallus [Reaction:R-GGA-8985943] p-Y701-STAT1 dimerizes - Gallus gallus [BlackBoxEvent:R-GGA-8985983] p-Y701-STAT1 dimer translocates from the cytosol to the nucleus - Gallus gallus
inferredFrom	[Pathway:R-HSA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-9860927
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9860931] Response of endothelial cells to shear stress
(inferredTo)	[Pathway:R-HSA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells

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