Reactome | Regulation of Complement cascade

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Regulation of Complement cascade Show undefined attributes

compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10826917
displayName	Regulation of Complement cascade
eventOf	[Pathway:R-GGA-166658] Complement cascade - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23338] regulation of complement activation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-976768] Factor H binds to C3b - Gallus gallus [Reaction:R-GGA-1006169] Factor H binds host cell surface markers - Gallus gallus [Reaction:R-GGA-981728] Factor H binds to membrane-associated C3b - Gallus gallus [Reaction:R-GGA-8851436] CFHR dimers bind C3b - Gallus gallus [Reaction:R-GGA-976801] Complement factor I complex formation - Gallus gallus [Reaction:R-GGA-976810] Complement factor I binds to extracellular Factor H:C3b - Gallus gallus [Reaction:R-GGA-976743] Factor I inactivates plasma Factor H-bound C3b - Gallus gallus [Reaction:R-GGA-977359] Complement factor I binds to membrane-associated Factor H:C3b - Gallus gallus [Reaction:R-GGA-977371] Factor I inactivates Factor H-boundC3b - Gallus gallus [Reaction:R-GGA-981535] CD55 (DAF) binds C3bBb, C4bC2a - Gallus gallus [Reaction:R-GGA-2530453] Vitronectin (VTN) binds to C5b:C6:C7 - Gallus gallus [Reaction:R-GGA-2855047] Hydrolysis of internal thioester in C4b - Gallus gallus [Reaction:R-GGA-9021306] C1-Inh binds and inactivates C1r, C1s - Gallus gallus [Reaction:R-GGA-444647] C3a receptor binds anaphylatoxin C3a - Gallus gallus [Reaction:R-GGA-9957405] C5a binds C5a inhibitor - Gallus gallus [Reaction:R-GGA-8852580] Clusterin binds C5b-C7, C8, C9 - Gallus gallus [Reaction:R-GGA-8852716] Thrombin, ELANE cleave C5 - Gallus gallus [Reaction:R-GGA-8852809] CPN, CPB2 cleave C3a, C5a - Gallus gallus
inferredFrom	[Pathway:R-HSA-977606] Regulation of Complement cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of Complement cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-977606
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-166658] Complement cascade
(inferredTo)	[Pathway:R-HSA-977606] Regulation of Complement cascade

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