Reactome | p-T177-CDK6:CCND [nucleoplasm]

Schema > DefinedSet > Entries

catalystActivities	[CatalystActivity:10733139] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-GGA-9754129] CDK6 inhibitors bind CDK6 - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10733138
displayName	p-T177-CDK6:CCND [nucleoplasm]
hasMember	[Complex:R-GGA-9755189] p-T177-CDK6:CCND1 [nucleoplasm] - Gallus gallus [Complex:R-GGA-9755190] p-T177-CDK6:CCND2 [nucleoplasm] - Gallus gallus [Complex:R-GGA-9755185] p-T177-CDK6:CCND3 [nucleoplasm] - Gallus gallus
inDisease	false
inferredFrom	[CandidateSet:R-HSA-8949896] p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-9756822] p-T177-CDK6:CCND [nucleoplasm] - Homo sapiens
maxDepth	3
name	p-T177-CDK6:CCND
negativelyRegulates	[NegativeRegulation:10814857] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]'
producedByEvent	[Reaction:R-GGA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Gallus gallus
schemaClass	DefinedSet
species	[Species:49591] Gallus gallus
stId	R-GGA-9756822

(input)	[Reaction:R-GGA-9754129] CDK6 inhibitors bind CDK6
(regulator)	[NegativeRegulation:10814857] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]'
(physicalEntity)	[CatalystActivity:10733139] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
(output)	[Reaction:R-GGA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
(inferredTo)	[CandidateSet:R-HSA-8949896] p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] [DefinedSet:R-HSA-9756822] p-T177-CDK6:CCND [nucleoplasm]

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