Reactome | ITGA4:ITGB1 binds natalizumab

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ITGA4:ITGB1 binds natalizumab Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10817599
displayName	ITGA4:ITGB1 binds natalizumab
eventOf	[Pathway:R-GGA-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Gallus gallus [Pathway:R-GGA-202733] Cell surface interactions at the vascular wall - Gallus gallus [Pathway:R-GGA-216083] Integrin cell surface interactions - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9679740] ITGA4:ITGB1 binds natalizumab - Homo sapiens
input	[Complex:R-GGA-198201] ITGA4:ITGB1 [plasma membrane] [ProteinDrug:R-ALL-9679737] natalizumab [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	ITGA4:ITGB1 binds natalizumab
output	[Complex:R-GGA-9679842] ITGA4:ITGB1:natalizumab [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9679740
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell [Pathway:R-GGA-202733] Cell surface interactions at the vascular wall [Pathway:R-GGA-216083] Integrin cell surface interactions
(inferredTo)	[Reaction:R-HSA-9679740] ITGA4:ITGB1 binds natalizumab

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