Reactome | ITGA4:ITGB1 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-GGA-202759] integrin alpha4beta1:JAM2:JAM3 [plasma membrane] - Gallus gallus [Complex:R-GGA-9679842] ITGA4:ITGB1:natalizumab [plasma membrane] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Gallus gallus [Reaction:R-GGA-9679740] ITGA4:ITGB1 binds natalizumab - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10747060
displayName	ITGA4:ITGB1 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-GGA-198007] ITGA4 [plasma membrane] [EntityWithAccessionedSequence:R-GGA-57596] ITGB1 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-198201] ITGA4:ITGB1 [plasma membrane] - Homo sapiens
maxDepth	2
memberOf	[DefinedSet:R-GGA-4205071] Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] - Gallus gallus [DefinedSet:R-GGA-4205068] Integrin alpha3beta1, alpha4beta1 [plasma membrane] - Gallus gallus
name	ITGA4:ITGB1
schemaClass	Complex
species	[Species:49591] Gallus gallus
stId	R-GGA-198201
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasMember)	[DefinedSet:R-GGA-4205071] Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] [DefinedSet:R-GGA-4205068] Integrin alpha3beta1, alpha4beta1 [plasma membrane]
(input)	[Reaction:R-GGA-9679740] ITGA4:ITGB1 binds natalizumab [Reaction:R-GGA-202706] Integrin alpha4beta1 binds JAM2:JAM3
(hasComponent)	[Complex:R-GGA-202759] integrin alpha4beta1:JAM2:JAM3 [plasma membrane] [Complex:R-GGA-9679842] ITGA4:ITGB1:natalizumab [plasma membrane]
(inferredTo)	[Complex:R-HSA-198201] ITGA4:ITGB1 [plasma membrane]