Reactome | HEXB cleaves the terminal GalNAc from DS

Schema > Reaction > Entries

HEXB cleaves the terminal GalNAc from DS Show undefined attributes

catalystActivity	[CatalystActivity:10816629] beta-N-acetylhexosaminidase activity of bHEXB [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10816631
displayName	HEXB cleaves the terminal GalNAc from DS
eventOf	[Pathway:R-GGA-2024101] CS/DS degradation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-1793186] IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:21608] dermatan sulfate proteoglycan catabolic process
inferredFrom	[Reaction:R-HSA-9638075] HEXB cleaves the terminal GalNAc from DS - Homo sapiens
input	[SimpleEntity:R-ALL-2065269] ChEBI:63516 chain [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	HEXB cleaves the terminal GalNAc from DS
output	[SimpleEntity:R-ALL-1605658] GalNAc [lysosomal lumen] [SimpleEntity:R-ALL-2105025] IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl [lysosomal lumen]
precedingEvent	[Reaction:R-GGA-1793182] IDS hydrolyses dermatan sulfate (Chebi:63517 chain) - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9638075
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2024101] CS/DS degradation
(precedingEvent)	[Reaction:R-GGA-1793186] IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS
(inferredTo)	[Reaction:R-HSA-9638075] HEXB cleaves the terminal GalNAc from DS

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