Reactome | IDS hydrolyses dermatan sulfate (Chebi:63517 chain)

Schema > Reaction > Entries

IDS hydrolyses dermatan sulfate (Chebi:63517 chain) Show undefined attributes

catalystActivity	[CatalystActivity:10774458] iduronate-2-sulfatase activity of IDS dimer [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10774593
displayName	IDS hydrolyses dermatan sulfate (Chebi:63517 chain)
eventOf	[Pathway:R-GGA-2024101] CS/DS degradation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9638075] HEXB cleaves the terminal GalNAc from DS - Gallus gallus [Reaction:R-GGA-2105001] HEXA cleaves the terminal GalNAc from DS - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:21608] dermatan sulfate proteoglycan catabolic process
inferredFrom	[Reaction:R-HSA-1793182] IDS hydrolyses dermatan sulfate (Chebi:63517 chain) - Homo sapiens
input	[SimpleEntity:R-ALL-2065213] ChEBI:63517 chain [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	IDS hydrolyses dermatan sulfate (Chebi:63517 chain)
output	[SimpleEntity:R-ALL-2065269] ChEBI:63516 chain [lysosomal lumen] [SimpleEntity:R-ALL-1606845] SO4(2-) [lysosomal lumen]
precedingEvent	[Reaction:R-GGA-1606789] ARSB hydrolyses DS - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1793182
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2024101] CS/DS degradation
(precedingEvent)	[Reaction:R-GGA-9638075] HEXB cleaves the terminal GalNAc from DS [Reaction:R-GGA-2105001] HEXA cleaves the terminal GalNAc from DS
(inferredTo)	[Reaction:R-HSA-1793182] IDS hydrolyses dermatan sulfate (Chebi:63517 chain)

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