Reactome | ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus

Schema > BlackBoxEvent > Entries

ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus Show undefined attributes

category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10816599
displayName	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
eventOf	[Pathway:R-GGA-9634635] Estrogen-stimulated signaling through PRKCZ - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9632910] ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus - Homo sapiens
input	[Complex:R-GGA-109855] p-T185,Y187 MAPK1 dimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
output	[Complex:R-GGA-109856] p-Y185,Y187 MAPK1 dimer [nucleoplasm]
precedingEvent	[Reaction:R-GGA-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Gallus gallus
regulatedBy	[PositiveRegulation:10816600] Positive regulation by 'PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-9632910
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9634635] Estrogen-stimulated signaling through PRKCZ
(inferredTo)	[BlackBoxEvent:R-HSA-9632910] ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus

Cite Us!