Reactome | Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex

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Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex Show undefined attributes

category	dissociation
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10812997
displayName	Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex
eventOf	[Pathway:R-GGA-8964616] G beta:gamma signalling through CDC42 - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8964599] Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex - Homo sapiens
input	[Complex:R-GGA-9014577] G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex
output	[EntityWithAccessionedSequence:R-GGA-195017] ARHGEF6 [cytosol] [Complex:R-GGA-182921] CDC42:GTP [plasma membrane] [Complex:R-GGA-167434] G-protein beta-gamma complex [plasma membrane] [EntityWithAccessionedSequence:R-GGA-162629] PAK1 [cytosol]
precedingEvent	[Reaction:R-GGA-8964614] PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-8964599
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-8964616] G beta:gamma signalling through CDC42
(inferredTo)	[Reaction:R-HSA-8964599] Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex

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