Reactome | JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4

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JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 Show undefined attributes

catalystActivity	[CatalystActivity:10811406] transmembrane receptor protein tyrosine kinase activity of IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10811408
displayName	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
eventOf	[Pathway:R-GGA-8984722] Interleukin-35 Signalling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-8983983] p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor - Gallus gallus
inferredFrom	[BlackBoxEvent:R-HSA-8950453] JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-8952783] IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-GGA-8952780] IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-GGA-8983996] STAT1 and STAT4 associate with IL12RB2:IL6ST receptor - Gallus gallus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-8950453
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-8984722] Interleukin-35 Signalling
(precedingEvent)	[BlackBoxEvent:R-GGA-8983983] p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
(inferredTo)	[BlackBoxEvent:R-HSA-8950453] JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4

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