Reactome | The NLRP1 inflammasome

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827021
displayName	The NLRP1 inflammasome
eventOf	[Pathway:R-GGA-622312] Inflammasomes - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-879201] Bcl-2 and Bcl-XL bind NLRP1 - Gallus gallus [BlackBoxEvent:R-GGA-844447] NLRP1 senses MDP - Gallus gallus [Reaction:R-GGA-879222] MDP:NLRP1 binds ATP - Gallus gallus [Polymerisation:R-GGA-844438] NLRP1 oligomerizes - Gallus gallus
inferredFrom	[Pathway:R-HSA-844455] The NLRP1 inflammasome - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	The NLRP1 inflammasome
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-844455
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-622312] Inflammasomes
(inferredTo)	[Pathway:R-HSA-844455] The NLRP1 inflammasome

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