Reactome | NLRP1 senses MDP

Schema > BlackBoxEvent > Entries

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10762694
displayName	NLRP1 senses MDP
eventOf	[Pathway:R-GGA-844455] The NLRP1 inflammasome - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-879222] MDP:NLRP1 binds ATP - Gallus gallus
inferredFrom	[BlackBoxEvent:R-HSA-844447] NLRP1 senses MDP - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-561196] CARD8 [cytosol] [SimpleEntity:R-ALL-708341] MDP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NLRP1 senses MDP
output	[Complex:R-GGA-877370] MDP:NLRP1 [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-844447
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-844455] The NLRP1 inflammasome
(precedingEvent)	[Reaction:R-GGA-879222] MDP:NLRP1 binds ATP
(inferredTo)	[BlackBoxEvent:R-HSA-844447] NLRP1 senses MDP

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