Reactome | CAIR + Aspartate + ATP => SAICAR + ADP + Pi

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CAIR + Aspartate + ATP => SAICAR + ADP + Pi Show undefined attributes

catalystActivity	[CatalystActivity:10735676] phosphoribosylaminoimidazolesuccinocarboxamide synthase activity of PAICS octamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10735678
displayName	CAIR + Aspartate + ATP => SAICAR + ADP + Pi
eventOf	[Pathway:R-GGA-73817] Purine ribonucleoside monophosphate biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-73800] SAICAR => AICAR + Fumarate - Gallus gallus
inferredFrom	[Reaction:R-HSA-73805] CAIR + Aspartate + ATP => SAICAR + ADP + Pi - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-111395] CAIR [cytosol] [SimpleEntity:R-ALL-29448] L-Asp [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CAIR + Aspartate + ATP => SAICAR + ADP + Pi 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP => (2S)-2-(5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido)succinate + ADP + phosphate + 2 H(+) 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + ADP + orthophosphate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-111399] SAICAR [cytosol]
precedingEvent	[Reaction:R-GGA-73806] AIR + CO2 => CAIR - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-73805
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-73817] Purine ribonucleoside monophosphate biosynthesis
(precedingEvent)	[Reaction:R-GGA-73800] SAICAR => AICAR + Fumarate
(inferredTo)	[Reaction:R-HSA-73805] CAIR + Aspartate + ATP => SAICAR + ADP + Pi

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