Reactome | phospho-MDM2 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-GGA-6792868] PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10799391
displayName	phospho-MDM2 [nucleoplasm]
endCoordinate	491
hasModifiedResidue	[ModifiedResidue:10799389] O-phospho-L-threonine at 218 (in Homo sapiens) [ModifiedResidue:10746866] O-phospho-L-serine at 166 (in Homo sapiens) [ModifiedResidue:10746867] O-phospho-L-serine at 188 (in Homo sapiens)
inDisease	false
inferredFrom	[CandidateSet:R-HSA-6792895] p-T218,S166,S188-MDM2, p-S166,S188-MDM2 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6792862] p-S166,S188,T218-MDM2 [nucleoplasm] - Homo sapiens
maxDepth	1
name	phospho-MDM2 p-S166,S188,T218-MDM2 F1NGX6
producedByEvent	[Reaction:R-GGA-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Gallus gallus
referenceEntity	[ReferenceGeneProduct:uniprot:F1NGX6] UniProt:F1NGX6
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49591] Gallus gallus
stId	R-GGA-6792862
startCoordinate	1

(hasComponent)	[Complex:R-GGA-6792868] PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm]
(inferredTo)	[CandidateSet:R-HSA-6792895] p-T218,S166,S188-MDM2, p-S166,S188-MDM2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6792862] p-S166,S188,T218-MDM2 [nucleoplasm]
(output)	[Reaction:R-GGA-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218

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