Reactome | PXLP-K333-GADL1 decarboxylates acidic AAs

Schema > Reaction > Entries

PXLP-K333-GADL1 decarboxylates acidic AAs Show undefined attributes

catalystActivity	[CatalystActivity:10798786] carboxy-lyase activity of PXLP-K333-GADL1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10798788
displayName	PXLP-K333-GADL1 decarboxylates acidic AAs
eventOf	[Pathway:R-GGA-8963693] Aspartate and asparagine metabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6787757] PXLP-K333-GADL1 decarboxylates acidic AAs - Homo sapiens
input	[DefinedSet:R-ALL-6787759] GADL1 substrates [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-K333-GADL1 decarboxylates acidic AAs H(+) + L-aspartate => beta-alanine + CO2 3-sulfino-L-alanine + H(+) => CO2 + hypotaurine H(+) + L-cysteate => CO2 + taurine
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [DefinedSet:R-ALL-6787762] GADL1 products [cytosol]
precedingEvent	[Reaction:R-GGA-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Gallus gallus [Reaction:R-GGA-6797627] ASPG hydrolyses L-Asn to L-Asp - Gallus gallus [Reaction:R-GGA-372448] SLC25A12,13 exchange L-Glu and L-Asp - Gallus gallus [Reaction:R-GGA-70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-6787757
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-8963693] Aspartate and asparagine metabolism
(inferredTo)	[Reaction:R-HSA-6787757] PXLP-K333-GADL1 decarboxylates acidic AAs

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