Reactome | BCKDK phosphorylates BCKDH

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BCKDK phosphorylates BCKDH Show undefined attributes

catalystActivity	[CatalystActivity:10796575] protein kinase activity of BCKDK dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10796577
displayName	BCKDK phosphorylates BCKDH
eventOf	[Pathway:R-GGA-70895] Branched-chain amino acid catabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24669] negative regulation of amino acid metabolic process
inferredFrom	[Reaction:R-HSA-5693148] BCKDK phosphorylates BCKDH - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [Complex:R-GGA-70019] BCKDH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	BCKDK phosphorylates BCKDH ATP + L-seryl-(3-methyl-2-oxobutanoate dehydrogenase) => ADP + H(+) + O-phospho-L-seryl-(3-methyl-2-oxobutanoate dehydrogenase)
output	2 × [SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [Complex:R-GGA-5693120] p-BCKDH [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5693148
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-70895] Branched-chain amino acid catabolism
(inferredTo)	[Reaction:R-HSA-5693148] BCKDK phosphorylates BCKDH

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