Reactome | STAT3 [cytosol]

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STAT3 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-GGA-8950547] IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] - Gallus gallus [Complex:R-GGA-8983998] IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] - Gallus gallus
consumedByEvent	[BlackBoxEvent:R-GGA-9701524] STAT3 is phosphorylated downstream of active ALK - Gallus gallus [BlackBoxEvent:R-GGA-8987014] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 - Gallus gallus [BlackBoxEvent:R-GGA-8982165] IL19:IL20RA:p?JAK1:IL20RB binds STAT3 - Gallus gallus [BlackBoxEvent:R-GGA-9009072] STAT3 phosphorylation - Gallus gallus [BlackBoxEvent:R-GGA-8987063] IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 - Gallus gallus [BlackBoxEvent:R-GGA-8987104] IL20:IL20RA:JAK1:IL20RB:p?JAK2,p?JAK3 binds STAT3 - Gallus gallus [Reaction:R-GGA-6784323] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 - Gallus gallus [Reaction:R-GGA-8875816] STAT3 binds activated MET receptor - Gallus gallus [Reaction:R-GGA-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10754925
displayName	STAT3 [cytosol]
endCoordinate	770
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-539044] STAT3 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-GGA-380756] STAT family members [cytosol] - Gallus gallus [DefinedSet:R-GGA-9006868] STAT1,STAT3,STAT4,STAT5 [cytosol] - Gallus gallus [DefinedSet:R-GGA-9009216] STAT1, STAT2, STAT3, STAT4, STAT5 [cytosol] - Gallus gallus
name	STAT3 STAT3 A0A8V1AAG1
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8V1AAG1] UniProt:A0A8V1AAG1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49591] Gallus gallus
stId	R-GGA-539044
startCoordinate	2

Referrals

(hasComponent)	[Complex:R-GGA-8950547] IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] [Complex:R-GGA-8983998] IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] [Complex:R-GGA-8987189] IL24:IL22RA1:p-JAK1:IL20RB:STAT3 [plasma membrane] [Complex:R-GGA-8987123] IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3:STAT3 [plasma membrane] [Complex:R-GGA-9007112] STAT3:STAT5A,STAT5B [cytosol] [Complex:R-GGA-8987032] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] [Complex:R-GGA-8982170] IL19:IL20RA:p-JAK1:IL20RB:STAT3 [plasma membrane] [Complex:R-GGA-6784795] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] [Complex:R-GGA-8875815] HGF:p-4Y-MET dimer:STAT3 [plasma membrane] [Complex:R-GGA-9958926] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane]
(input)	[BlackBoxEvent:R-GGA-8987063] IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 [BlackBoxEvent:R-GGA-8987104] IL20:IL20RA:JAK1:IL20RB:p?JAK2,p?JAK3 binds STAT3 [BlackBoxEvent:R-GGA-9701524] STAT3 is phosphorylated downstream of active ALK [BlackBoxEvent:R-GGA-8987014] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 [BlackBoxEvent:R-GGA-8982165] IL19:IL20RA:p?JAK1:IL20RB binds STAT3 [Reaction:R-GGA-6784323] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 [BlackBoxEvent:R-GGA-9009072] STAT3 phosphorylation [Reaction:R-GGA-8875816] STAT3 binds activated MET receptor [Reaction:R-GGA-9958878] Tyrosine phosphorylated IL6ST binds STAT3
(hasMember)	[DefinedSet:R-GGA-380756] STAT family members [cytosol] [DefinedSet:R-GGA-9006868] STAT1,STAT3,STAT4,STAT5 [cytosol] [CandidateSet:R-GGA-9007142] STAT3,STAT5,(STAT3:STAT5) [cytosol] [DefinedSet:R-GGA-9009216] STAT1, STAT2, STAT3, STAT4, STAT5 [cytosol] [DefinedSet:R-GGA-1433551] STATs [cytosol] [DefinedSet:R-GGA-1112559] STAT1, STAT3 [cytosol] [DefinedSet:R-GGA-6786055] STAT3,STAT6 [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-539044] STAT3 [cytosol]

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