Reactome | Homologues of CFLAR(1-376) [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-GGA-9697749] TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-5675456] FLIP(L) and procaspase-8 form heterodimer - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10737017
displayName	Homologues of CFLAR(1-376) [cytosol]
hasMember	[EntityWithAccessionedSequence:R-GGA-51925] CASP8 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-GGA-51925-2] CASP18 [cytosol] - Gallus gallus
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-51925] CFLAR(1-376) [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3465408] CFLAR(1-376) [cytosol] - Homo sapiens
maxDepth	2
name	Homologues of CFLAR(1-376)
negativelyRegulates	[NegativeRegulation:10737020] Negative regulation by 'CFLAR(1-376) [cytosol]'
schemaClass	DefinedSet
species	[Species:49591] Gallus gallus
stId	R-GGA-51925-3

(hasComponent)	[Complex:R-GGA-9697749] TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] [Complex:R-GGA-9697746] TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] [Complex:R-GGA-3465431] DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane]
(input)	[Reaction:R-GGA-5675456] FLIP(L) and procaspase-8 form heterodimer
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-3465408] CFLAR(1-376) [cytosol] [EntityWithAccessionedSequence:R-HSA-51925] CFLAR(1-376) [cytosol]
(regulator)	[NegativeRegulation:10737020] Negative regulation by 'CFLAR(1-376) [cytosol]'