Reactome | SLC30A8 transports Zn2+ from cytosol to secretory granule

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SLC30A8 transports Zn2+ from cytosol to secretory granule Show undefined attributes

catalystActivity	[CatalystActivity:10759451] zinc ion transmembrane transporter activity of SLC30A8 [secretory granule membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10759453
displayName	SLC30A8 transports Zn2+ from cytosol to secretory granule
eventOf	[Pathway:R-GGA-435368] Zinc efflux and compartmentalization by the SLC30 family - Gallus gallus [Pathway:R-GGA-264876] Insulin processing - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-437136] SLC30A8 transports Zn2+ from cytosol to secretory granule - Homo sapiens
input	2 × [SimpleEntity:R-ALL-5339575] H+ [secretory granule lumen] [SimpleEntity:R-ALL-29426] Zn2+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC30A8 transports Zn2+ from cytosol to secretory granule ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically
output	2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-216785] Zn2+ [secretory granule lumen]
precedingEvent	[Reaction:R-GGA-442422] SLC39A1-4 transports Zn2+ from extracellular region to cytosol - Gallus gallus [Reaction:R-GGA-442317] ZIP6 and ZIP14 mediate zinc influx into cells - Gallus gallus [Reaction:R-GGA-442387] ZIP8 mediates zinc influx into cells - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-437136
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-264876] Insulin processing [Pathway:R-GGA-435368] Zinc efflux and compartmentalization by the SLC30 family
(inferredTo)	[Reaction:R-HSA-437136] SLC30A8 transports Zn2+ from cytosol to secretory granule

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