Reactome | Insulin processing

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Insulin processing Show undefined attributes

compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen [Compartment:13959] COPII-coated ER to Golgi transport vesicle [Compartment:17963] Golgi lumen [Compartment:1462052] secretory granule lumen [Compartment:216813] secretory granule membrane [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10826529
displayName	Insulin processing
eventOf	[Pathway:R-GGA-2980736] Peptide hormone metabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19560] insulin processing
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-264997] P4HB mediates disulfide bond formation in Proinsulin - Gallus gallus [Reaction:R-GGA-9817575] ERO1B oxidizes P4HB - Gallus gallus [BlackBoxEvent:R-GGA-265010] Proinsulin translocates from the endoplasmic reticulum to the Golgi - Gallus gallus [Reaction:R-GGA-437139] ZnT8 transports zinc into the Golgi apparatus - Gallus gallus [Reaction:R-GGA-9820566] ZnT5 transports zinc into the golgi apparatus - Gallus gallus [Reaction:R-GGA-264976] Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium - Gallus gallus [BlackBoxEvent:R-GGA-265153] Proinsulin:Zinc:Calcium complex translocates to immature secretory granule - Gallus gallus [Reaction:R-GGA-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Gallus gallus [Reaction:R-GGA-437136] SLC30A8 transports Zn2+ from cytosol to secretory granule - Gallus gallus [BlackBoxEvent:R-GGA-265177] Exocyst complex formation - Gallus gallus
inferredFrom	[Pathway:R-HSA-264876] Insulin processing - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Insulin processing
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-264876
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2980736] Peptide hormone metabolism
(inferredTo)	[Pathway:R-HSA-264876] Insulin processing

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