Reactome | phytoceramide + H2O => stearate + phytosphingosine

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:433600] N-acylsphingosine amidohydrolase activity of ACER3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:433625] D'Eustachio, P, 2009-08-22
dbId	433578
displayName	phytoceramide + H2O => stearate + phytosphingosine
eventOf	[Pathway:R-GGA-433584] Sphingolipid metabolism - Gallus gallus
inferredFrom	[Reaction:R-HSA-428262] ACER3 hydrolyzes phytoceramide - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-9025544] phytoceramide [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	phytoceramide + H2O => stearate + phytosphingosine
output	[SimpleEntity:R-ALL-428237] phytosphingosine [cytosol] [SimpleEntity:R-ALL-428198] STEA [early endosome]
precedingEvent	[Reaction:R-GGA-433593] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - Gallus gallus
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-433578
summation	[Summation:433623] ACER3 (alkaline ceramidase 3) catalyzes the hydrolysis of ph...
updateTrackers	[UpdateTracker:9779959] Update Tracker - [Reaction:433578] phytoceramide + H2O => stearate + phytosphingosine - v64:[add_removeInput]

(updatedInstance)	[UpdateTracker:9779959] Update Tracker - [Reaction:433578] phytoceramide + H2O => stearate + phytosphingosine - v64:[add_removeInput]
(hasEvent)	[Pathway:R-GGA-433584] Sphingolipid metabolism
(inferredTo)	[Reaction:R-HSA-428262] ACER3 hydrolyzes phytoceramide

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